Hepatitis B virus escape mutants induced by antiviral therapy

Hepatitis B virus S gene escape mutants

Hepatitis B virus (HBV) can be classified into nine immunological subtypes or eight genotypes. The most prevalent genotypes in Asia are genotypes B and C. HBV is transmitted parenteraly and can produce either asymptomatic or symptomatic disease. Although the consequences of acute hepatitis B can be severe, serious sequelae are associated with chronic infections. HBV seroprevalence ranges from i...

Reported Series Resolution Took Hepatitis B Virus "escape" Mutants

days, and about 5-20% of patients still required laparotomy. 3 What is the prognosis after an ectopic pregnancy? Among 55 American women treated by salpingectomy or salpingostomy and followed up for three to 41 months 30 became pregnant again: 24 pregnancies were intrauterine and six were repeat ectopics.32 In a four to eight year follow up of 110 Finnish women (42 treated by conservative surge...

Antiviral therapy and resistance with hepatitis B virus infection.

Hepatitis B virus (HBV) infection is still the most common cause of hepatocellular carcinoma and liver cirrhosis world wide. Recently, however, there has been quite dramatic improvement in the understanding of HBV associated liver disease and its treatment. It has become clear that high viral replication is a major risk factor for the development of both cirrhosis and hepatocellular carcinoma. ...

Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy

Hepatitis B Virus Reactivation Associated With Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus.

Background: Direct-acting antiviral agents (DAAs) are used increasingly to treat hepatitis C virus (HCV) infection. Reports were published recently on hepatitis B virus (HBV) reactivation (HBV-R) in patients with HBV–HCV co-infection. Hepatitis B virus reactivation, defined as an abrupt increase in HBV replication in patients with inactive or resolved HBV infection, may result in clinically sig...